The Role of Traumatic Microvascular
Injury in the Pathophysiology of Traumatic Brain Injury
Douglas S. DeWitt, Ph.D.
OBJECTIVES
At the conclusion of this program, the participants will be able to:
1. Define and discuss the major pathophysiological effects of head injury on
the cerebral vasculature.
2. Outline the primary mechanisms that contribute to the major pathophysiological
effects of head injury on the cerebral vasculature.
3. Define the role of gap junctions in normal cerebral vascular function and
discuss the contribution of impaired gap junction function to traumatic cerebral
vascular injury.
4. Describe the clinical consequences of traumatic cerebral vascular dysfunction.