UCSF Neurological Surgery faculty since 1990
 
Read about Dr. Noble's current research
 
Dr. Noble has an established expertise in the field of neurotrauma and hers is one of few laboratories that has developed models of both traumatic brain and spinal cord injury in the mouse that mimic the human conditions. Such modeling has provided a unique opportunity to study transgenic animals and has been used to identify specific factors that influence vascular permeability and inflammation and mediate cell injury after either traumatic spinal cord or brain injury. Dr. Noble is funded by the National Institutes of Health for these studies.
 
The extent of functional recovery after spinal cord injury is a consequence of both the initial mechanical destruction of tissue and secondary factors that collectively contribute to additional tissue damage. Traumatic brain injury results in progressive neuronal cell death that occurs in regions that are relatively remote from the site of initial injury. An objective of the Noble laboratory has been to characterize and define the time course of this regional neuronal vulnerability and to determine the factors that contribute to cell injury.
 
 
Education, Training, and Previous Positions
 
1975: BS, University of Utah
1975-76: Physical Therapist, Cedars-Sinai Medical Center, Los Angeles
1977-78: Physical Therapist, University of California Medical Center, Los Angeles
1982: PhD, University of California at Los Angeles
1982-83: Instructor, Department of Anatomy, University of Maryland, Baltimore
1983-85: Research Associate, Department of Anatomy, Georgetown University
1985-90: Assistant Research Neuroanatomist, Neurology Department, UCSF
1990-93: Assistant Professor, Neurological Surgery, UCSF
1993-99: Associate Professor, Neurological Surgery, UCSF
 
Selected Professional Memberships and Appointments
 
Society for Neuroscience
American Association of Anatomists
Society for Neurotrauma
Editorial Board: Journal of Neurotrauma
 
Contact
 
Linda J. Noble PhD
University of California San Francisco
521 Parnassus Avenue, Room C224
San Francisco, CA 94143-0520
 
Selected Recent Publications
 
Chang EF, Wong RJ, Vreman HJ, Igarashi T, Galo E, Sharp FR, Stevenson DK, Noble-Haeusslein LJ. Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. J Neurosci 2003;23:3689-96.
 
Fan P, Yamauchi T, Noble LJ, Ferriero DM. Age-dependent differences in glutathione peroxidase activity after traumatic brain injury. J Neurotrauma 2003;20:437-45.
 
Goussev S, Hsu JY, Lin Y, Tjoa T, Maida N, Werb Z, Noble-Haeusslein LJ. Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing. J Neurosurg 2003;99(2 Suppl):188-97.
 
Noble LJ, Donovan F, Igarashi T, Goussev S, Werb Z. Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci 2002;22:7526-35.
 
Tjoa T, Strausbaugh HJ, Maida N, Dazin PF, Rosen SD, Noble-Haeusslein LJ. The use of flow cytometry to assess neutrophil infiltration in the injured murine spinal cord. J Neurosci Methods 2003;129:49-59.
 
Tong W, Igarashi T, Ferriero DM, Noble LJ. Traumatic brain injury in the immature mouse brain: characterization of regional vulnerability. Exp Neurol 2002;176:105-16.
 
Whetstone WD, Hsu JY, Eisenberg M, Werb Z, Noble-Haeusslein LJ. Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J Neurosci Res 2003;74:227-39.