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Bareyre, F.M., K.E.
Saatman, M.A. Helfaer, G. Sinson, J.D. Weisser,
A.L. Brown, and T.K. McIntosh, Alterations in
Ionized and Total Blood Magnesium after
Experimental Traumatic Brain Injury:
Relationship to Neurobehavioral Outcome and
Neuroprotective Efficacy of Magnesium
Chloride.
J.
Neurochem., v. 73, pp. 271-280;
1999.
Scherbel U,
Raghupathi R, Nakamura M, Saatman KE,
Trojanowski JQ, Neugebauer E, Marino MW,
McIntosh TK: Differential acute and chronic
responses of tumor necrosis factor-deficient
mice to experimental brain injury. Proc
Natl Acad Sci U S A. 1999 Jul 20;96(15):8721-6.
Nakamura M, Saatman
KE, Galvin JE, Scherbel U, Raghupathi R,
Trojanowski JQ, McIntosh TK: Increased
vulnerability of NFH-LacZ transgenic mouse to
traumatic brain injury-induced behavioral
deficits and cortical damage. J
Cereb Blood Flow Metab. 1999 Jul;19(7):762-70.
Philips MF, Muir JK,
Saatman KE, Raghupathi R, Lee VM, Trojanowski
JQ, McIntosh TK: Survival and integration of
transplanted postmitotic human neurons following
experimental brain injury in immunocompetent
rats. J
Neurosurg. 1999 Jan;90(1):116-24.
Nakagawa Y, Nakamura
M, McIntosh TK, Rodriguez A, Berlin JA, Smith
DH, Saatman KE, Raghupathi R, Clemens J, Saido
TC, Schmidt ML, Lee VM, Trojanowski JQ:
Traumatic brain injury in young, amyloid-beta
peptide overexpressing transgenic mice induces
marked ipsilateral hippocampal atrophy and
diminished Abeta deposition during aging. J
Comp Neurol. 1999 Aug
30;411(3):390-8.
Nakamura M,
Raghupathi R, Merry DE, Scherbel U, Saatman KE,
Mcintosh TK: Overexpression of Bcl-2 is
neuroprotective after experimental brain injury
in transgenic mice. J
Comp Neurol. 1999 Oct 4;412(4):681-92.
Smith DH, Chen XH,
Nonaka M, Trojanowski JQ, Lee VM, Saatman KE,
Leoni MJ, Xu BN, Wolf JA, Meaney DF:
Accumulation of amyloid beta and tau and the
formation of neurofilament inclusions following
diffuse brain injury in the pig. J
Neuropathol Exp Neurol. 1999
Sep;58(9):982-92.
Zhang C, Raghupathi
R, Saatman KE, LaPlaca MC, McIntosh TK: Regional
and temporal alterations in DNA fragmentation
factor (DFF)-like proteins following
experimental brain trauma in the rat. J
Neurochem. 1999 Oct;73(4):1650-9.
Sanderson KL,
Raghupathi R, Saatman KE, Martin D, Miller G,
McIntosh TK: Interleukin-1 receptor antagonist
attenuates regional neuronal cell death and
cognitive dysfunction after experimental brain
injury. J
Cereb Blood Flow Metab. 1999 Oct;19(10):1118-25.
Saatman KE, Zhang C,
Bartus RT, McIntosh TK: Behavioral efficacy of
posttraumatic calpain inhibition is not
accompanied by reduced spectrin proteolysis,
cortical lesion, or apoptosis. J
Cereb Blood Flow Metab. 2000
Jan;20(1):66-73.
Graham DI,
Raghupathi R, Saatman KE, Meaney D, McIntosh TK:
Tissue tears in the white matter after lateral
fluid percussion brain injury in the rat:
relevance to human brain injury. Acta
Neuropathol (Berl). 2000
Feb;99(2):117-24.
Nakagawa Y, Reed L,
Nakamura M, McIntosh TK, Smith DH, Saatman KE,
Raghupathi R, Clemens J, Saido TC, Lee VM,
Trojanowski JQ: Brain trauma in aged transgenic
mice induces regression of established abeta
deposits. Exp
Neurol. 2000 May;163(1):244-52.
Chen X.-H., D.F.
Meaney, B.-N. Xu, M. Nonaka, T.K. McIntosh, J.A.
Wolf, K.E. Saatman, and D.H. Smith, Evolution of
Neurofilament Subtype Accumulation in Axons
Following Diffuse Brain Injury in the Pig. J.
Neuropathol. Exp. Neurol., v. 58, pp. 516-524;
1999.
Steward O., P.E. Schauwecker,
L. Guth, Z. Zhang, M. Fujiki, D. Inman, J.
Wrathall, G. Kempermann, F.H. Gage, K.E.
Saatman, R. Raghupathi, T. McIntosh, Genetic
Approaches to Neurotrauma Research:
Opportunities and Potential Pitfalls of Murine
Models. Exp.
Neurol., v. 157, pp. 19-42;
1999.
Muir, J.K., R. Raghupathi, K.E.
Saatman, C.A. Wilson, V.M.-Y. Lee, J.Q.
Trojanowski, M.F. Philips, and T.K. McIntosh,
Terminally Differentiated Human Neurons (hNT)
Survive and Integrate Following Transplantation
into the Traumatically-Injured Rat Brain. J.
Neurotrauma., v. 16(5), pp. 403-414;
1999.
Guluma, K.Z., K.E. Saatman, A.
Brown, R. Raghupathi, and T.K. McIntosh,
Sequential Pharmacotherapy with Magnesium
Chloride and Basic Fibroblast Growth Factor
(bFGF) after Fluid Percussion Brain Injury
Results in Less Neuromotor Efficacy than that
Achieved with Magnesium Alone.
J. Neurotrauma, v. 16(4), pp. 311-321;
1999.
Cheney, J.A., A.L. Brown, F.M.
Bareyre, A.B. Russ, J.D. Weisser, H.A. Ensinger,
A. Leusch, R. Raghupathi, and K.E. Saatman, The
Novel Compound LOE908 Attenuates Acute
Neuromotor Dysfunction but not Cognitive
Impairment or Cortical Tissue Loss Following
Traumatic Brain Injury in Rats. J.
Neurotrauma, v. 17(1), pp. 83-91;
2000.
Emery, D.L., R. Raghupathi,
K.E. Saatman, I. Fischer, M.S. Grady, and T.K.
McIntosh, Bilateral Growth-Related Protein
Expression Suggests a Transient Increase in
Regenerative Potential Following Brain Trauma.
J.
Comp. Neurol. 424:521-531,
2000
Graham, D.I., R. Raghupathi,
K.E. Saatman, D. Meaney, and T.K. McIntosh,
Tissue Tears in the White Matter after Lateral
Fluid Percussion Brain Injury in the Rat:
Relevance to Human Brain Injury. Acta
Neuropathol., v. 99, pp. 117-124;
2000.
Saatman, K.E., C. Zhang, R.T.
Bartus, and T.K. McIntosh, Behavioral Efficacy
of Posttraumatic Calpain Inhibition is not
Accompanied by Reduced Spectrin Proteolysis,
Cortical Lesion, or Apoptosis. J. Cereb. Blood
Flow Metab., v. 20(1), pp. 66-73;
2000.
Bareyre, F.M., K.E. Saatman, R.
Raghupathi, and T.K. McIntosh: Postinjury
Treatment with Magnesium Chloride Attenuates
Cortical Damage After Traumatic Brain Injury in
Rats. J. Neurotrauma, v. 17, pp. 1029-1039;
2000.
Galvin, J.E., M. Nakamura, T.K.
McIntosh, K.E. Saatman, D. Sampathu, R.
Raghupathi, V. M.-Y. Lee and J.Q. Trojanowski,
Neurofilament-Rich Intraneuronal Inclusions
Exacerbate Neurodegenerative Sequelae of Brain
Trauma in NFH/LacZ Transgenic Mice. Exp.
Neurol., v. 165, pp. 77-89; 2000.
Bareyre FM, Saatman
KE, Raghupathi R, McIntosh TK: Postinjury
treatment with magnesium chloride attenuates
cortical damage after traumatic brain injury in
rats. J
Neurotrauma. 2000 Nov;17(11):1029-39.
Smith FM, Raghupathi
R, MacKinnon MA, McIntosh TK, Saatman KE, Meaney
DF, Graham DI: TUNEL-positive staining of
surface contusions after fatal head injury in
man.
Acta Neuropathol (Berl). 2000 Nov;100(5):537-45.
Blaha GR, Raghupathi
R, Saatman KE, McIntosh TK: Brain-derived
neurotrophic factor administration after
traumatic brain injury in the rat does not
protect against behavioral or histological
deficits. Neuroscience.
2000;99(3):483-93.
Saatman, K.E., F.M.
Bareyre, M.S. Grady and T.K. McIntosh: Acute
Cytoskeletal Alterations and Cell Death Induced
by Experimental Brain Injury are Attenuated by
Magnesium Treatment and Exacerbated by Magnesium
Deficiency. J.Neuropath.
Exp. Neurol., v. 60, pp. 183-194;
2001.
Bareyre, F.M., R.Raghupathi,
K.E. Saatman and T.K. McIntosh, DNase I
Disinihibition is Predominantly Associated with
Actin Hyperpolymerization after Traumatic Brain
Injury. J.Neurochem.,
v. 76, pp. 1-10; 2001.
Cheney JA, Weisser
JD, Bareyre FM, Laurer HL, Saatman KE,
Raghupathi R, Gribkoff V, Starrett JE Jr,
McIntosh TK: The maxi-K channel opener
BMS-204352 attenuates regional cerebral edema
and neurologic motor impairment after
experimental brain injury. J
Cereb Blood Flow Metab. 2001 Apr;21(4):396-403.
Shaw, K., M.-A.
MacKinnon, R. Raghupathi, K.E. Saatman, T.K.
McIntosh, and D.I. Graham, TUNEL-positive
Staining in White and Grey Matter After Fatal
Head Injury in Man. Clin.
Neuropathol., v. 20, pp. 106-112;
2001.
Riess P, Bareyre FM,
Saatman KE, Cheney JA, Lifshitz J, Raghupathi R,
Grady MS, Neugebauer E, McIntosh TK: Effects of
chronic, post-injury Cyclosporin A
administration on motor and sensorimotor
function following severe, experimental
traumatic brain injury. Restor
Neurol Neurosci. 2001;18(1):1-8.
Longhi, L., K.E.
Saatman, R. Raghupathi, H.L. Laurer, P.M.
Lenzlinger, P. Riess, E. Neugebauer, J.Q.
Trojanowski, V. M.-Y. Lee, M.S. Grady, D.I.
Graham and T.K. McIntosh, A Review and Rationale
for the Use of Genetically Engineered Animals in
the Study of Traumatic Brain Injury. J.
Cereb. Blood Flow Metab., v. 21, pp. 1241-1258;
2001.
Laurer HL, Bareyre
FM, Lee VM, Trojanowski JQ, Longhi L, Hoover R,
Saatman KE, Raghupathi R, Hoshino S, Grady MS,
McIntosh TK: Mild head injury increasing the
brain's vulnerability to a second concussive
impact. J
Neurosurg. 2001 Nov;95(5):859-70.
Williams, S., R.
Raghupathi, M.-A. MacKinnon, T.K. McIntosh, K.E.
Saatman, and D.I. Graham, In Situ DNA
Fragmentation Occurs in White Matter up to 12
Months After Head Injury in Man. Acta
Neuropathol., v. 102, pp. 581-590;
2001.
Huh, J.W., H.L. Laurer, R.
Raghupathi, M.A. Helfaer, and K.E. Saatman,
Rapid Loss and Partial Recovery of Neurofilament
Immunostaining Following Focal Brain Injury in
Mice. Exp.
Neurol., v. 175, pp. 198-208;
2002.
Fowler J, MacKinnon
MA, Raghupathi R, Saatman KE, McIntosh TK,
Graham DI: Age does not influence DNA
fragmentation in the hippocampus after fatal
traumatic brain injury in young and aged humans
compared with controls. Clin
Neuropathol. 2002 Jul-Aug;21(4):156-62.
Laurer, H.L., A.N.
Ritting, A.B. Russ, F.M. Bareyre, R. Raghupathi,
K.E. Saatman, Effects of Underwater Sound
Exposure on Neurologic Function and Brain
Histology. Ultrasound
Med. Biol., v. 28, pp. 965-973;
2002.
Riess, P., C. Zhang, K.E.
Saatman, H.L. Laurer, L.G. Longhi, R.
Raghupathi, P.M. Lenzlinger, J. Lifshitz, J.
Boockvar, E. Neugebauer, E.Y. Snyder, and T.K.
McIntosh, Transplanted Neural Stem Cells
Survive, Differentiate, and Improve Neurologic
Motor Function Following Experimental Traumatic
Brain Injury: Neurosurg.,
v. 51, pp. 1043-1054; 2002.
Marciano PG,
Eberwine JH, Ragupathi R, Saatman KE, Meaney DF,
McIntosh TK: Expression profiling following
traumatic brain injury: a review. Neurochem
Res. 2002 Oct;27(10):1147-55.
Saatman, K.E., B.
Abai, A. Grosvenor, C. Vorwerk, D.H. Smith, and
D.F. Meaney, "Traumatic Axonal Injury Results in
Biphasic Calpain Activation and Retrograde
Transport Impairment in Mice."
J. Cereb. Blood Flow Metab., v. 23, pp. 34-42;
2003.
Lifshitz J, Friberg
H, Neumar RW, Raghupathi R, Welsh FA, Janmey P,
Saatman KE, Wieloch T, Grady MS, McIntosh TK:
Structural and functional damage sustained by
mitochondria after traumatic brain injury in the
rat: evidence for differentially sensitive
populations in the cortex and hippocampus. J
Cereb Blood Flow Metab. 2003 Feb;23(2):219-31.
O'Dell DM, Muir JK,
Zhang C, Bareyre FM, Saatman KE, Raghupathi R,
Welsh F, McIntosh TK: Lubeluzole treatment does
not attenuate neurobehavioral dysfunction or CA3
hippocampal neuronal loss following traumatic
brain injury in rats. Restor
Neurol Neurosci. 2000;16(2):127-134.
Thompson HJ, Tkacs
NC, Saatman KE, Raghupathi R, McIntosh TK:
Hyperthermia following traumatic brain injury: a
critical evaluation. Neurobiol
Dis. 2003 Apr;12(3):163-73.
Smith DH, Uryu K,
Saatman KE, Trojanowski JQ, McIntosh TK: Protein
accumulation in traumatic brain injury. Neuromolecular
Med. 2003;4(1-2):59-72.
Huh JW, Raghupathi
R, Laurer HL, Helfaer MA, Saatman KE: Transient
loss of microtubule-associated protein 2
immunoreactivity after moderate brain injury in
mice. J
Neurotrauma. 2003 Oct;20(10):975-84.
Emery DL, Royo NC,
Fischer I, Saatman KE, McIntosh TK: Plasticity
following injury to the adult central nervous
system: is recapitulation of a developmental
state worth promoting? J
Neurotrauma. 2003 Dec;20(12):1271-92.
Marciano PG,
Brettschneider J, Manduchi E, Davis JE, Eastman
S, Raghupathi R, Saatman KE, Speed TP, Stoeckert
CJ Jr, Eberwine JH, McIntosh TK: Neuron-specific
mRNA complexity responses during hippocampal
apoptosis after traumatic brain injury. J
Neurosci. 2004 Mar 24;24(12):2866-76.
Wilson S, Raghupathi
R, Saatman KE, MacKinnon MA, McIntosh TK, Graham
DI: Continued in situ DNA fragmentation of
microglia/macrophages in white matter weeks and
months after traumatic brain injury. J
Neurotrauma. 2004 Mar;21(3):239-50.
Hoover RC, Motta M,
Davis J, Saatman KE, Fujimoto ST, Thompson HJ,
Stover JF, Dichter MA, Twyman R, White HS,
McIntosh TK: Differential effects of the
anticonvulsant topiramate on neurobehavioral and
histological outcomes following traumatic brain
injury in rats. J Neurotrauma.
2004 May;21(5):501-12.
Book Chapters
McIntosh, T.K., M. Juhler, R.
Raghupathi, K.E. Saatman, and D.H. Smith,
?Secondary Brain Injury: Neurochemical and
Cellular Mediators,? in Traumatic Brain Injury,
D.W. Marion, ed., Thieme, New York; pp. 39-54;
1999.
Bareyre, F.M., T.K. McIntosh, R.
Raghupathi, D.H. Smith, G.P. Sinson, and K.E.
Saatman, "Neuroprotection in Traumatic Brain
Injury: Glutamate- and Calcium-related
Pharmacology," in Excitatory Amino Acids: Ten
Years Later, E.A. Cavalheiro, ed., IOS Press;
pp. 305-314;
2000.
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