Cognitive Dysfunction, Phosphatases & TBI

Edward Dixon, Univ. of Pittsburgh

At the conclusion of this presentation, attendees will be able to:

1. Describe key cellular functions of protein phosphatase 2B (calcineurin)
2. Recognize how both synaptic plasticity and memory is thought to depend on the balance between opposing molecular regulatory factors, including protein kinases and phosphatases.
3. Discuss the effects of TBI on calcineurin signaling.
4. Discuss the therapeutic potential of calcineurin inhibition in TBI