Preclinical Models of Blast-Induced Neurotrauma

Ibolja Cernak, M.D. Ph.D.

Johns Hopkins University Applied Physics Laboratory, Laurel, MD

At the conclusion of this lecure, the participants will be able to:

1. Outline the importance of blast-induced neurotrauma and describe related clinical findings;

1. Define and discuss the pathobiology of blast-induced neurotrauma, and differentiate primary, secondary, tertiary, and quaternary blast-induced neurological consequences;

1. Describe the currently available preclinical models of blast-induced neurotrauma, and discuss the pros and cons of these models;

1. Discuss the most important research directions concerning the diagnosis, monitoring, treating and mitigating blast-induced neurotrauma.