Speaker: George M. Smith

Title of Talk: Molecular/genetic manipulation of extrinsic axon guidance factors for spinal cord regeneration

1) Discuss the advantages of using viral gene therapy to establish growth supportive pathways and gradients within the adult CNS.

2) Identify the advantages for using guidance molecules to “recapitulate” a developmental-like program.

3) Discuss advantages of targeting axon regeneration to aid reformation of laminar specific circuits.

4) Discuss application of guidance pathways in long distance growth of axons from transplanted neurons and its potential in circuit reconstruction.