EDGERTON

Objectives:

•  Present a general concept of the interaction of supraspinal, spinal and sensory sources of control of posture and locomotion.

•  Demonstrate that the spinal circuitry in conjunction with sensory input can be modulated in a way that can support the recovery of full weightbearing locomotion following a mid thoracic complete spinal cord transection and the rat.

•  Demonstrate the application of activity dependent mechanisms, including pharmacological interventions and epidural stimulation, and recovering for weightbearing locomotion following spinal cord injury.

•  Formulate the general neurophysiological principles which underlie the recovery of locomotion following a complete spinal cord injury.