Acute and sub-acute management of traumatic brain injury (TBI) poses a daunting challenge for the medical community, both for short-term functional recovery and for the often years long rehabilitation. Many patients with concussion histories report cognitive problems that are comorbid with persistent headaches and psychiatric conditions such as post-traumatic stress disorder (PTSD) and depression. Unfortunately, many conventional treatments for these conditions have not proven effective. This symposium will provide an introduction to neuromodulation techniques that hold significant promise for ameliorating many of the problems faced by TBI patients. First, Dr. Adamson will illustrate the efficacy of repetitive transcranial magnetic stimulation (rTMS) as a treatment for the executive function deficits seen in veterans with mild to moderate TBI (with a special emphasis on PTSD). Dr. Siddiqi will propose novel personalized targeting approaches based on the individualized identification of circuits associated with specific disorders, including depression, TBI and PTSD. Dr. Leung will review findings from recent neuroimaging studies assessing the mechanisms underlying the development of post-concussive headache, clinical and neuroimaging evidence supporting the use of rTMS in managing post-concussive headache, as well as other co-morbid symptoms. Dr. Monti will discuss severe TBI populations, describing preliminary efficacy and safety data from an innovative clinical trial where the cortico-thalamo-cortical mesocircuit is upregulated in patients surviving severe brain injury, via low intensity focused ultrasound pulsation (LIFUP). Finally, Dr. Coetzee will provide an overview of focused ultrasound as a useful tool for enhancing important functional capabilities in neurotrauma patients.
At the conclusion of this session, attendees will be able to: