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Description & Objectives S11


Mechanisms of Recovery of Function from Mouse to Man SCI


Spinal cord injury (SCI), a complex condition, has garnered decades of invasive, cellular research to understand the neuropathological cascades. These basic science studies in animal models hold the promise of predicting potential interventions for human SCI. This translational session will explore innovative mechanistic interventions and their efficacy in people with spinal cord injury (SCI). Advances from basic science and pre-clinical studies are leading to in-person use. Speakers will provide details of foundational animal studies and their translation into human treatment to improve recovery of function. New research findings from epidural stimulation, neurorehabilitation and myelin-associated neuroplasticity research will be presented.


At the conclusion of this session, attendees will be able to:

  1. Understand the role of basic science research studies in the improved treatment of people living with spinal cord injury.
  2. Be able to identify the latest advances in epidural stimulation in neuroplasticity and improvement in function.
  3. Recognize the new role of myelin plasticity in recovery from SCI and the mechanisms that increase this plasticity.
  4. Be familiar with cellular and molecular factors that regulate neurorehabilitation effects in deleterious or beneficial ways.