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Description & Objectives LW1

SESSION TITLE

Deploying Best Practices for Scientific Rigor in Neurotrauma Research TEAM

DESCRIPTION

This will be an interactive workshop focusing on issues of scientific rigor that are particularly relevant for animal models in neurotrauma research.   The framework will be NIH's new requirements for considerations of scientific rigor in all types of grant applications.  The target audience is trainees and early career scientists but scientists at any career stage are welcome.  Topics for discussion include:  1) Rigorous study design including identifying the transition between preliminary studies vs. tests of concept, defining the beginning and end of a study, random allocation, group formulation across a range of practices from one subject at a time to all groups at the same time, blinding, unbiased sample collection, testing to a foregone conclusion; 2) Minimizing un-recognized bias in sample collection and data analysis including avoiding various forms of p-hacking, controlling for multiple measures, reporting bias and the file drawer problem; 3) Implementing considerations of sex as a biological variable (SABV), and authentication of key biological/chemical resources; and 4) Evolving expectations and practices regarding reporting (a moving target).

EDUCATIONAL OBJECTIVES

At the conclusion of this session, attendees will be able to:

  1. Develop an understanding of principles of rigorous study design including the distinction between preliminary studies and formal hypothesis-testing, group formulation in studies done over time and avoidance of testing to a foregone conclusion.

  2. Develop an understanding of principals of unbiased sample collection and rigorous data analysis to avoid various forms of p-hacking including controlling for multiple measures and negative results.

  3. Develop an understanding of strategies to address sex as a biological variable and authentication of key biological/chemical resources.

  4. Deploying best practices for scientific rigor in neurotrauma research